Martínez-Reyes, Inmaculada, and Navdeep S. Chandel. "Mitochondrial TCA cycle metabolites control physiology and disease." Nature communications 11.1 (2020): 102.
Lee, Chi Fung, et al. "Targeting NAD+ metabolism as interventions for mitochondrial disease." Scientific Reports 9.1 (2019): 3073.
Wu, Nan, et al. "Alpha-ketoglutarate: physiological functions and applications." Biomolecules & therapeutics 24.1 (2016): 1.
Legendre, F., et al. "Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite." World Journal of Microbiology and Biotechnology 36 (2020): 1-11.
Gyanwali, Bibek, et al. "Alpha-Ketoglutarate dietary supplementation to improve health in humans." Trends in Endocrinology & Metabolism 33.2 (2022): 136-146.
Zhang, Zhenzhen, et al. "α‐ketoglutarate delays age‐related fertility decline in mammals." Aging Cell 20.2 (2021): e13291.
Demidenko, Oleksandr, et al. "Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test." Aging (albany NY) 13.22 (2021): 24485.
Zdzisińska, Barbara, Aleksandra Żurek, and Martyna Kandefer-Szerszeń. "Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use." Archivum immunologiae et therapiae experimentalis 65 (2017): 21-36.
Eid, Fady. "α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain." (2022).
Morris IV, John P., et al. "α-Ketoglutarate links p53 to cell fate during tumour suppression." Nature 573.7775 (2019): 595-599.
Carey, Bryce W., et al. "Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells." Nature 518.7539 (2015): 413-416.
Shahmirzadi, Azar Asadi, et al. "Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice." Cell metabolism 32.3 (2020): 447-456.
Su, Yuan, et al. "Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK." Aging (Albany NY) 11.12 (2019): 4183.
Moussaieff, A., et al. (2015). Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metabolism, 21(3), 392-402.
Xu, W., et al. (2016). Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell, 19, 17-30.
Sekita, Yoichi, et al. "AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation." Stem Cell Research & Therapy 12.1 (2021): 1-15.
Tanosaki, Sho, et al. "Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes." Inflammation and Regeneration 41 (2021): 1-9.
Tran, Khoa A., Caleb M. Dillingham, and Rupa Sridharan. "The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance." Journal of Biological Chemistry 294.14 (2019): 5408-5419.
Shyh-Chang, Ng, et al. "Influence of threonine metabolism on S-adenosylmethionine and histone methylation." Science 339.6116 (2013): 222-226.
Joshi, Kanak, et al. "Mechanisms that regulate the activities of TET proteins." Cellular and Molecular Life Sciences 79.7 (2022): 363.
Abla, Houda, et al. "The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?." Seminars in cell & developmental biology. Vol. 98. Academic Press, 2020.
Wink, Lily, Richard A. Miller, and Gonzalo G. Garcia. "Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation." Immunity & Ageing 19.1 (2022): 1-20.
Martin-Montalvo, Alejandro, et al. "Metformin improves healthspan and lifespan in mice." Nature communications 4.1 (2013): 2192.
Acosta-Rodríguez, Victoria, et al. "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice." Science 376.6598 (2022): 1192-1202.
Strong, Randy, et al. "Rapamycin‐mediated mouse lifespan extension: late‐life dosage regimes with sex‐specific effects." Aging Cell 19.11 (2020): e13269.
the ca akg longevity results in male mice in the 2020 paper were not statistically significant... you really should quote p values or at least point this out....
Thank you very much on a great and insightful written article. Do you know if there’s a supplement that combines both Ca-AKG and GLYNAC and where that can be found? Thanks again
Hi Patrick thanks for stopping by! None that I'm aware of. One of the reasons is because of the dosage required. Combining them into a single capsule or tablet would not hold enough of each ingredient. And a powder form would taste and smell awful due to the natural sulfur component in NAC. Your best bet is to purchase CA-AKG, Glycine, then NAC separately. A new company offers 3600mg of NAC in a single concentrated capsule. But they're not yet on the market so you may wish to monitor their updates. https://visviva.health/
Thank you for this article . It is clearly written and easy to follow for a lay person and is helping to answer my questions regarding the efficacy and feasibility of taking NMN, GLYNAC and CA-AKG, either together or alone. CA-AKG seems like a wiser choice than NMN. I would like to learn more about the pros and cons of GLYNAC and whether it would be wise to take it together with CA-AKG
if you have existing medications be sure to check how each of them might interact with your medications or consult your physician first. interactions between different longevity compounds themselves haven't been studied extensively - natural compounds aren't patentable so funding is scarce. GlyNAC is the first truly successful combination. I have been taking Ca-AKG and GlyNAC together personally.
That is the combo that I have been thinking of , as well. I am curious as to the dosages that you have settled on , if you would care to share. Thank you
References:
Martínez-Reyes, Inmaculada, and Navdeep S. Chandel. "Mitochondrial TCA cycle metabolites control physiology and disease." Nature communications 11.1 (2020): 102.
Lee, Chi Fung, et al. "Targeting NAD+ metabolism as interventions for mitochondrial disease." Scientific Reports 9.1 (2019): 3073.
Wu, Nan, et al. "Alpha-ketoglutarate: physiological functions and applications." Biomolecules & therapeutics 24.1 (2016): 1.
Legendre, F., et al. "Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite." World Journal of Microbiology and Biotechnology 36 (2020): 1-11.
Gyanwali, Bibek, et al. "Alpha-Ketoglutarate dietary supplementation to improve health in humans." Trends in Endocrinology & Metabolism 33.2 (2022): 136-146.
Zhang, Zhenzhen, et al. "α‐ketoglutarate delays age‐related fertility decline in mammals." Aging Cell 20.2 (2021): e13291.
Demidenko, Oleksandr, et al. "Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test." Aging (albany NY) 13.22 (2021): 24485.
Zdzisińska, Barbara, Aleksandra Żurek, and Martyna Kandefer-Szerszeń. "Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use." Archivum immunologiae et therapiae experimentalis 65 (2017): 21-36.
Eid, Fady. "α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain." (2022).
Morris IV, John P., et al. "α-Ketoglutarate links p53 to cell fate during tumour suppression." Nature 573.7775 (2019): 595-599.
Carey, Bryce W., et al. "Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells." Nature 518.7539 (2015): 413-416.
Shahmirzadi, Azar Asadi, et al. "Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice." Cell metabolism 32.3 (2020): 447-456.
Su, Yuan, et al. "Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK." Aging (Albany NY) 11.12 (2019): 4183.
Moussaieff, A., et al. (2015). Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metabolism, 21(3), 392-402.
Xu, W., et al. (2016). Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell, 19, 17-30.
Sekita, Yoichi, et al. "AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation." Stem Cell Research & Therapy 12.1 (2021): 1-15.
Tanosaki, Sho, et al. "Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes." Inflammation and Regeneration 41 (2021): 1-9.
Vazquez-Martin, Alejandro, et al. "Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate." Aging (Albany NY) 8.7 (2016): 1330.
Tran, Khoa A., Caleb M. Dillingham, and Rupa Sridharan. "The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance." Journal of Biological Chemistry 294.14 (2019): 5408-5419.
Shyh-Chang, Ng, et al. "Influence of threonine metabolism on S-adenosylmethionine and histone methylation." Science 339.6116 (2013): 222-226.
Joshi, Kanak, et al. "Mechanisms that regulate the activities of TET proteins." Cellular and Molecular Life Sciences 79.7 (2022): 363.
Abla, Houda, et al. "The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?." Seminars in cell & developmental biology. Vol. 98. Academic Press, 2020.
Wink, Lily, Richard A. Miller, and Gonzalo G. Garcia. "Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation." Immunity & Ageing 19.1 (2022): 1-20.
Martin-Montalvo, Alejandro, et al. "Metformin improves healthspan and lifespan in mice." Nature communications 4.1 (2013): 2192.
Acosta-Rodríguez, Victoria, et al. "Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice." Science 376.6598 (2022): 1192-1202.
Strong, Randy, et al. "Rapamycin‐mediated mouse lifespan extension: late‐life dosage regimes with sex‐specific effects." Aging Cell 19.11 (2020): e13269.
the ca akg longevity results in male mice in the 2020 paper were not statistically significant... you really should quote p values or at least point this out....
Thank you very much on a great and insightful written article. Do you know if there’s a supplement that combines both Ca-AKG and GLYNAC and where that can be found? Thanks again
Hi Patrick thanks for stopping by! None that I'm aware of. One of the reasons is because of the dosage required. Combining them into a single capsule or tablet would not hold enough of each ingredient. And a powder form would taste and smell awful due to the natural sulfur component in NAC. Your best bet is to purchase CA-AKG, Glycine, then NAC separately. A new company offers 3600mg of NAC in a single concentrated capsule. But they're not yet on the market so you may wish to monitor their updates. https://visviva.health/
Thank you for this article . It is clearly written and easy to follow for a lay person and is helping to answer my questions regarding the efficacy and feasibility of taking NMN, GLYNAC and CA-AKG, either together or alone. CA-AKG seems like a wiser choice than NMN. I would like to learn more about the pros and cons of GLYNAC and whether it would be wise to take it together with CA-AKG
if you have existing medications be sure to check how each of them might interact with your medications or consult your physician first. interactions between different longevity compounds themselves haven't been studied extensively - natural compounds aren't patentable so funding is scarce. GlyNAC is the first truly successful combination. I have been taking Ca-AKG and GlyNAC together personally.
That is the combo that I have been thinking of , as well. I am curious as to the dosages that you have settled on , if you would care to share. Thank you
I'm sticking with the dosages used in the studies until new ones come out, which are 1g a day for Ca-AKG and 100mg/kg a day for GlyNAC